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Kratom Withdrawal Timeline, Symptoms & More

The kratom withdrawal timeline can vary from person to person, but it does follow a similar progression during the first two weeks. The experience is often very similar to opioid withdrawal with a few unique symptoms.

    The timeline for acute withdrawal typically lasts 4 to 7 days, followed by a post-acute phase. Because of the symptoms most clients experience, the rate of relapse is quite high. The following timeline can help you determine whether you or a loved one is going through withdrawal.

      Kratom Withdrawal Symptoms

      Some of the symptoms of kratom withdrawal can include:

      • Anxiety and Irritability
      • Depression (with or without suicidal ideation)
      • Dysphoria (a general sense of unease or unhappiness)
      • Hypertension (high blood pressure)
      • Repeated Yawning or Stretching
      • Rhinorrhea (extremely runny nose)
      • Insomnia
      • Mood Swings
      • Tremors
      • Muscle, Bone, and Joint Pain
      • Diarrhea and Nausea
      • Hallucinations

      The best thing you can do when experiencing kratom withdrawal is to enter a professional detox facility. Withdrawal is extremely unpleasant and could even be life threatening.

      Kratom Withdrawal Timeline

      There have not yet been enough studies performed to get a clear picture of kratom withdrawal in humans. We can look at some documented cases to get a rough idea of what is involved in the acute phase of withdrawal. Kratom withdrawal shares similarities to opioid withdrawal. Because of this, the timeline is similar as well. Depending on the amount and length of time that someone used kratom, the acute phase of withdrawal lasts roughly 4 to 7 days. It is recommended to seek medical help when facing kratom withdrawal.

      First 24 Hours

      Withdrawal symptoms begin around 12 hours from the last time someone used kratom. The first symptoms will be excessive sweating with an increase in anxiety. This starts off very mild and usually escalates over the first day. From roughly 12 to 24 hours after the last kratom use, individuals may experience:

      • Muscle Pain
      • Joint Pain
      • Bone Pain
      • Abdominal Pain
      • Nausea
      • Visual Distortions

      A fever is also expected to begin during the first day and may worsen as withdrawal continues. Anxiety will increase and insomnia is common during the first few days. Cravings for kratom may also begin at this point alongside mood swings. The appearance of mood swings and their intensity varies between people.

      Days 2 and 3

      During the next few days, depression may set in as well as cravings for kratom intensifying. The visual distortions that some people experience may disappear during this time. Tremors or shaking and impaired coordination usually appear during the second or third day. Insomnia, lack of appetite, and dehydration can worsen these symptoms. Fever will usually stabilize during this time.

      Days 4 Through 7

      Pain in the muscles, joints, or bones will decrease during this time. The abdominal pain may go away completely but nausea may persist for a few more days. Likewise, the tremors, fever, and coordination issues may resolve around the fourth day. A mild tremor may persist for a short time.

      Week 2 and Onwards (Post-Acute)

      The worst of the physical symptoms are usually resolved at this point. There may still be minor, lingering symptoms. While the physical symptoms may begin to lessen after the first two weeks, anxiety, depression, and cravings may still persist for some time.

      The weeks after acute withdrawal usually pose the highest risk of relapse. Once the physical symptoms are resolved and the memory of that discomfort fades, the psychological symptoms and cravings can make it seem more and more attractive to try kratom again.

      How Bad is Kratom Withdrawal?

      The lack of kratom regulation or quality control makes it hard to determine the exact doses that someone is taking. Higher doses of kratom will produce more intense withdrawal symptoms. Similar to opioid withdrawal, the longer kratom is used and the larger the amounts used, the greater the withdrawal symptoms will be.

      For a more exact look, a collaborative study performed by the Universiti Sains Malaysia and the University of Erlangen-Nuremberg in Germany seems to be definitive on this matter. They surveyed 293 regular kratom users and found that of those who used kratom for more than 6 months, more than half developed severe dependence. The average amount of the active metabolite mitragynine in the kratom drinks these subjects were taking was 79mg per drink. Those that had 3 or more kratom drinks per day had a much higher chance of developing kratom addiction, withdrawal, and cravings. Finally, the withdrawal symptoms become more intense the longer the drug is used.

      The intensity of kratom withdrawal symptoms is linked to the length of time it was used and the amounts used. Depending on the amounts used, kratom withdrawal can be expected to fall somewhere in the range of 4 to 7 days. The less kratom used, the less intense the withdrawals were and the shorter the symptoms persisted.

      If you or someone you know is experiencing kratom withdrawal, it is recommended to enter a detox center to reduce the risks and the discomfort. Once detox has been completed, treatment can begin at our treatment center in Atlanta.

      More About Kratom Addiction

      • Kratom Withdrawal Timeline, Symptoms & More
      • How Does Kratom Get You High?
      • Top 5 Dangers of Kratom Abuse
      • Using Kratom For Opiate Withdrawal
      • Kratom Addiction: Signs, Symptoms and Risks

      References

      • The Journal of the American Osteopathic Association: Pharmacology of Kratom – An Emerging Botanical Agent With Stimulant, Analgesic and Opioid-Like Effects
      • Child Mind Institute: Kratom – A Legal Drug That’s Dangerously Addictive
      • Addiction: Self-treatment of Opioid Withdrawal Using Kratom (Mitragynia Speciosa Korth)
      • Drug and Alcohol Dependence: Kratom (Mitragyna speciosa) Dependence, Withdrawal Symptoms and Craving in Regular Users

      Effects On The Brain

      The effects of kratom are dose-dependent. This means that doing small amounts will produce stimulant-like effects. Larger doses produce an opioid-like effect. The reason for this is not exactly clear, but the fact that different “strains” seem to have a proclivity for either stimulant or opioid type effects suggests that the particular balance of active compounds such as MPI and 7-HMG plays a role in the effect produced.

      The way that mitragynine works is very complex. It stimulates opioid receptors weakly but also interacts with serotonin and norepinephrine receptors. 7-HMG, while a more potent opioid receptor stimulator than mitragynine, is both present in the raw kratom plant and produced from the human body’s metabolism of mitragynine. Painkilling effects of mitragynine is more pronounced when taken orally as opposed to injected. This suggests an additional metabolite is produced during first-pass metabolism that may contribute to the painkilling effects. Injecting mitragynine straight into the brain of mice produced a similar painkilling effect as when taken orally. This also suggests that further metabolism may actually take place in the brain itself.

      The medical use of kratom is a very contentious subject within the medical community. There are those who believe that kratom can offer minor therapeutic benefits as a tool in certain health treatments. Others are much more cautious, citing the many risks associated with kratom. Kratom has already resulted in deaths through overdose. It is clear that it does have a potential for abuse as many treatment facilities can attest.

      Much more research is needed before a definitive and factually supported position can be taken by the medical community and government. In the meantime, proceed with caution and don’t hesitate to reach out via our contact form or find an Atlanta rehab to get help. Just because it isn’t a controlled substance doesn’t mean it isn’t dangerous. If you’re struggling with kratom use and want to stop, contact a detox center in Atlanta to have the best possible chance to safely stop using kratom.

      References

      • European Monitoring Centre for Drugs and Drug Addiction: Kratom Drug Profile
      • Bangkok Post: Kratom Leaves – Are They Really A Dangerous Drug?
      • BBC World News: The Drug Addictions Devastating Thai Villages
      • Pharmacognosy Research: The Evaluation of Antinociceptive Activity of Alkaloid, Methanolic, and Aqueous Extracts of Malaysian Mitragyna Speciosa Korth Leaves in Rats
      • Neuroscience and Biobehavioral Reviews: From Kratom to Mitragynine and Its Derivatives – Physiological and Behavioural Effects Related to Use, Abuse, and Addiction
      • Molecules: In Vitro and in Vivo Effects of Three Different Mitragyna Speciosa Korth Leaf Extracts on Phase II Drug Metabolizing Enzymes—Glutathione Transferases (GSTs)
      • Journal of the American Chemical Society: Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids – Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators
      • ACS Central Science: 7‑Hydroxymitragynine Is an Active Metabolite of Mitragynine and A Key Mediator of Its Analgesic Effects
      • Journal of Medicinal Chemistry: Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2
      • Frontiers in Psychiatry: Biochemical Benefits, Diagnosis, and Clinical Risks Evaluation of Kratom

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